High-dose 6-mercaptopurine infusions and tumor lysis syndrome
نویسندگان
چکیده
منابع مشابه
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
6-mercaptopurine (6MP) cytotoxicity is caused by thioguanine and methylthioinosine nucleotides. Thiopurine methylation occurs to a large extent in vivo and in vitro. In this reaction, S-adenosyl-L-methionine (AdoMet), produced from methionine and ATP, is converted into S-adenosyl-L-homocysteine (AdoHcy) which, in turn, is hydrolyzed into homocysteine. Remethylation of homocysteine into methioni...
متن کاملThe Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملSingle-dose rasburicase 6 mg in the management of tumor lysis syndrome in adults.
Rasburicase is currently approved at a dosage of 0.15-0.2 mg/kg once/day for 5 days in pediatric patients with cancer to lower plasma uric acid concentrations and manage tumor lysis syndrome (TLS). Information on rasburicase dosing in adults is limited, with some data on using rasburicase as a single dose instead of multiple daily doses. Therefore, we evaluated the efficacy of a single dose of ...
متن کاملTumor Lysis Syndrome
Hospital Physician September 2008 25 T umor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur as a result of the release of intracellular contents following lysis of malignant cells, typically after initiation of chemotherapy. The features of TLS include hyperphosphatemia, hyperuricemia, hypocalcemia, hyperkalemia, and acute kidney injury. These features are observed wh...
متن کاملSpontaneous Tumor Lysis Syndrome
Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, labo...
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ژورنال
عنوان ژورنال: Leukemia Research
سال: 1995
ISSN: 0145-2126
DOI: 10.1016/0145-2126(95)00022-g